Cannot profile single instance application

Symptoms:

When profiling application from dotMemory, Timeline is grayed out with "Timeline is not available for this type of application" text. All controller buttons ("Get Snapshot", "Force GC", "Detach", etc.) are disabled or don't exist at all.

Possible case:

You are trying to profile single instance application, which is already running. dotMemory cannot start profiling this type of apps, if they were already started.

Workaround:

Verify that application is not running and close it before pressing the "Profile" button (from dotMemory or "Profile Startup Project Memory" from VS).